Revolucion de Cuba is set to open on the former site of Rehab on Parliament Street in October.
The Latin American restaurant chain has invested £1m in a scheme to transform the former nightclub bar into a rustic themed cantina and cocktail bar.
As well as live music events, cocktail masterclasses and Cuban dining, the Harrogate venue will offer special events, networking events and private parties.
Harrogate will become Revolution de Cuba's 10th restaurant to open across the UK and general manager Will Kershaw said he was excited for the October opening.
He said: “Harrogate is widely recognised as a vibrant and cosmopolitan town and this is reflected in its growing ability to attract considerable investment as it evolves.
“With so many new developments, including the imminent launch of a new cinema, we felt this was the perfect time to bring something a little bit different to the town.
“We are looking forward to getting to know our fellow businesses and supporting the local events and causes that make Harrogate such a dynamic place to live and work.”
Mr Kershaw explained that decision to invest in Harrogate reflected the town’s "rising reputation" as a leading lifestyle destination in the North of England.
The restaurant opening is set to create 60 new jobs and Mr Kershaw said the team will be "very much a part of the local community as well as a feature of the bar and dining scene".
Revolucion de Cuba already has a presence in Leeds and Sheffield.