Demolition is set to begin at the Forensic Science Service on Sandbeck Way.
Planning permission was granted to Professional Demolition Ltd to remove the existing buildings, and Miller Homes have now submitted plans for 65 houses on the site.
The proposal was welcomed by local councillors because it targets brownfield and not rural land.
A Miller Homes spokesperson said: “This application was made as the buildings are no longer required and may pose a risk if they deteriorate. Work to remove the buildings is due to begin shortly.”
Unlike other proposed developments, such as Grove Road in Boston Spa and Spofforth Hill, the Home Office forensic labs, which closed in March 2012, is on brownfield land because of its former industrial/commercial use.
Elmet and Rothwell MP Alec Shelbrooke argued in Parliament that developed sites like the labs should be developed before greenfield is considered.
Miller Homes are now awaiting a decision from the council on their plans for 65 houses, which they say will create much needed housing in the area.
Work to remove the single and two storey labs, office buildings, the boiler house, and the chimney will soon begin and is expected to last two months.