Parts of the A64 will be closed overnight until November while the Highways Agency carries out a £2million resurfacing project.
The work, between Bramham and Malton, will be carried out in five phases and improve eight-and-a-half miles of the road network.
It includes carriageway resurfacing and patching, the renewal of road markings and road studs, reinstating traffic monitoring loops and renewing damaged road gullies.
Steven Wright, project manager for the Highways Agency, said: “This is a £2.2 million scheme which is taking place to prolong the life of the carriageway.
“The work has been designed to improve the surface of the road and improve safety for road users, while minimising the need for future works in these locations.
“We ask that drivers take care travelling through the roadworks and along the diversion routes, follow the traffic signs and any instructions of site staff.”
Between Tadcaster and Bilbrough Top, work is to be carried out to install solar powered road studs to improve safety.
Work is expected to be completed by November 12. It will take place between 8pm and 6am.
Overnight closures will take place from October 13-19 on the eastbound carriageway Bramham roundabout and Tadcaster Ings including closure of the A1(M) link road to A64.
Then from November 5-12 work will move to the westbound carriageway with closures between Bilbrough top and Headley Bar, near the A659, including all side roads and slip roads.
Diversions will be in place but Highways Agency bosses say the alternative routes will have a moderate impact on journey times.
For queries contact the Highways Agency Information Line by emailing email@example.com or calling 0300 123 5000.